Biodiesel and any co-products or intermediate chemicals produced and used from the biodiesel industry fall under the scope of the regulation related to chemical substances. Today, there are approximately 120 plants in the EU producing annually up to 6,100,000 tonnes of biodiesel, mainly located in Germany, Italy, Austria, France and Sweden. The criteria and methods for classification of physical hazards of substances and preparations used so far in the European Union were defined since 1967 in 67/548/EEC Directive so called "substances Directive" and in 1999/45/EC Directive, dealing with preparations. The European regulation 1272/2008 so called 'CLP - Classification, Packaging and Labelling' came into force on 2009 and introduced new rules on classification and labelling for substances and mixtures (hazard categorisation, labelling, MSDS ...). The impact of these new rules on the biodiesel and co-products is specifically investigated.